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Alpheus Bingham PERSONAL Born 13 October 1953 Married, six children EXPERIENCE Eli Lilly and Company Chairman, Innocentive (2001- ) Vice President, e-R&D (2000- ) Vice President, Sourcing Innovation and Portfolio Management (1998-2000) Responsible for research acquisitions, business development and alliance management as well as management of the R&D portfolio process. Executive Director, Project Management and Decision Sciences (1996-98) Oversee project management activities and strategy on projects with cumulative spend exceeding $500M. Projects span scope of target structure to global launch. Also responsible for Decision Science unit that consults in areas of decision-making, business planning and corporate strategy. Facilitate corporate portfolio management committee and chair decision phase operations committee. Staff size of 50-60 persons. Managing-Director, Lilly Development Centre (1993-1996) Responsible for all operations at Development Centre in Mont-Saint-Guibert, Belgium. Staff includes 200 scientists and support personnel. Scientific disciplines include: Toxicology, Metabolism, Chemistry, Pharmaceutics and Clinical Research. $30M budget excl Clinical grants. Director, Medical Planning and Development Strategy (1993-1993) Continuation of previous role with additional responsibility for Medical planning, training and reengineering activities. Director, Development Strategy (1992-1993) Spearhead implementation of strategic initiatives for accelerating product development. Main areas of focus: toxicology, medical, chemical development, and product development. Director, Pharmaceutical Sciences (1991-1992 ) Division responsible for accelerating clinical testing of new chemical entities. Conducts analytical characterization of bulk material and finished dosage forms, designs clinical formulations. About 50 scientists/staff. $5M budget (excl CT, large scale). Director, Pharmaceutical Development (1990-1991 ) Division responsible for all non-parenteral dosage development, drug delivery systems research and clinical trial materials from project team through production/market support. About 100 scientists/staff. $15M budget. Director, Pharmaceutical Development (1989-1990 ) Division esponsible for all dosage development, drug delivery systems research and clinical trial materials from project team through product launch About 100 scientists/staff. $15M budget. Head, Agricultural Products Formulation (1988-1989) Responsible for both animal and plant product formulations development. Supervised 25 scientists and technicians within two departments. Responsible for annual budget of $4-5 M. Head, Pharmaceutical Research (1986-1988) Responsible for project team support, preformulation research and the development of drug delivery systems. Supervised about 30 scientists. Budget $3M. Team Leader, Technical Services (1984-86) Responsible for process optimization and support for nearly sixty agricultural and pharmaceutical compounds. Supervised 8 scientists and 10 technicians. Research Scientist , Process Development (1983-84) Same as below. Supervised 2 to 3 persons. Senior Chemist, Process Development (1978-84) Process development, pilot plant scale-up, kinetic and mechanistic studies and process modelling.
Parish Chemical Company Organic chemist, process scale-up (1974)
EDUCATION Stanford University (1974-1977) Ph.D. Organic Chemistry (GPA = 3.9/4.0) Full funding via assistanships and fellowships. Brigham Young University (1970-1974) B.S. Chemistry (GPA = 3.6/4.0) Full four-year scholarship. Graduated cum laude. Riverbank High School (1967-1970) Valedictorian (GPA = 3.96/4.0)
PROFESSIONAL
American Chemical Society
(1975-92) SOCIETIES
Sigma Xi Research Society
(1978-93)
American Association of Pharmaceutical Scientists (1986-88)
Pharmaceutical Manufacturers Association
PMA Education and Research Institute Faculty (1989)
Pharmaceutical Development Steering Committee (1990-93)
EIRMA (1993-96)
IRI (1996-02)
Global Business Network (1996-98)
Santa Fe Institute (1998-2002)
Visiting Scholar, NCSA (1997-2002)
Research Technology Management Editorial Board (1998-2000)
Research Technology Editorial Board, Chairman (1999-2001)
iNNOVATION 2002 Steering Committee (2001-02)
Phase Forward Advisory Board (2001-02) INTERESTS Photography, art, squash.
Publications and Patents: PROVISIONAL PATENT APPLICATION: Open Sourced Innovation Markets INVENTOR: Bingham, Alpheus, Jr. LOCATION: USA ASSIGNEE: Lilly, Eli, and Co.
PROVISIONAL PATENT APPLICATION: Open sourced innovation INVENTOR: Bingham, Alpheus, Jr.; Schacht, Aaron LOCATION: USA ASSIGNEE: Lilly, Eli, and Co.
PATENT Sulfonamides INVENTOR: Bingham, Alpheus, Jr.; Pirkle, William Howard LOCATION: USA ASSIGNEE: Lilly, Eli, and Co. PATENT: European Pat. Appl. ; EP 143627 A1 DATE: 850605 APPLICATION: EP 84308161 (841126) *US 555765 (831128) PAGES: 18 pp. CODEN: EPXXDW LANGUAGE: English IDENTIFIERS: benzenesulfonamide, pyrimidinesulfonamide CA: 103(19)160216y
PATENT Stabilization of a novel halogenating compound and stabilized halogenating compositions ISSUED: US #4240988 12/23/80 (issued in 29 additional countries) INVENTOR: Bingham, Alpheus, Jr. LOCATION: USA ASSIGNEE: Lilly, Eli, and Co. PATENT: European Pat. Appl. EP 15080 DATE: 800903 APPLICATION: United States US 8648 DATE: 790201 PAGES: 28 pp. CODEN: EPXXDW LANGUAGE: English IDENTIFIERS: phosphite halogen complex halogenating agent, cephemcarboxylate halogenation
CA: 103(19)160216y JOURNAL Tunaxanthin: occurrence and absolute stereochemistry AUTHOR(S): Bingham, Alpheus, Jr.; Wilkie, Donald W.; Mosher, Harry S. LOCATION: Dep. Chem., Stanford Univ., Stanford, CA, USA JOURNAL: Comp. Biochem. Physiol. B DATE: 1979 VOLUME: 62B NUMBER: 4 PAGES: 489-95 CODEN: CBPBB8 ISSN: 0305-0491 LANGUAGE: English IDENTIFIERS: tunaxanthin Sebastes Oxyjulis CA: 91(21)171910e
DISSERTATION Stereochemistry of 3-hydroxy-epsilon-carotenoids AUTHOR(S): Bingham, Alpheus, Jr. LOCATION: Stanford Univ., Stanford, Calif. DATE: 1978 PAGES: 118 pp. CODEN: DABBBA LANGUAGE: English CITATION: Diss. Abstr. Int. B 1978, 38(12, Pt. 1), 5934 AVAIL: Univ. Microfilms Int. IDENTIFIERS: hydroxy epsilon carotenoid, stereochem hydroxy epsilon carotenoid CA: 89(15)129752p
JOURNAL Epimeric 3,3'-dihydroxy-.epsilon.,.epsilon.-carotenes from the skin of the yellow Costa Rican frog, Atelopus chiriquiensis AUTHOR(S): Bingham, Alpheus; Mosher, Harry S.; Andrewes, A. G. LOCATION: Dep. Chem., Stanford Univ., Stanford, Calif. JOURNAL: J. Chem. Soc., Chem. Commun. DATE: 1977 NUMBER: 3 PAGES: 96-7 IDENTIFIERS: chiriquixanthin Atelopus carotene structure, configuration CA: 87(3)23554u
Presentations and Lectures: "XXX" A. Bingham, Nature Biotechnology, San Diego, California, November 2001. "XXX" A. Bingham, e-Pharma Summitt, Philadelphia, Pennsylvania, September2001. "XXX" A. Bingham, MIT-Stanford, Stanford, California, September 2001. "XXX" A. Bingham, Frost and Sullivan Conference, Philadelphia, Pennsylvania, August 2001. "XXX" A. Bingham, Pharma Directions, Barcelona, Spain, June 2001. "Panel Moderator" A. Bingham, Pharma Directions, Cancun, Mexico, February 2001. "e-R&D Panel Discussion" A. Bingham, Eye-for-Pharma Symposium, Basel, Switzerland, November 2000. "Trends in e-R&D" A. Bingham, IMPACC, Washington D.C., November 2000. "Future of e-R&D" A. Bingham, American Association of Pharmaceutical Sciences, Indianapolis, Indiana, October 2000. "Trends in Chemistry" A. Bingham, Symposium of Medicinal Chemistry, Tokyo, Japan, November, 1999. "HBS Case Study on Technology" A. Bingham, University of Illinois, September, 1999. "Mind, Modelling and Magritte" A. Bingham, University of Illinois, 1999. "Management Decision Making and Statistical Moments" A. Bingham, University of Illinois, Business School, 1999. "Modelling the Development Process" A. Bingham, Maximizing the Efficiency of Drug Development, Management centre of Europe, Brussels, Belgium, Apr 1995, Sep 1995, April 1996. "From Pharmaceutical Development to Finished Product" A. Bingham, PMA Education and Research Institute, Basic Course, Denver, CO, June 1990, Jan 1991, Jan 1992 "Drug Delivery Systems" A. Bingham, Pharmacy Education Series, Eli Lilly and Company, 1989, 1990. "Insulin Delivery Systems" A. Bingham, Diabetes Education Program, Eli Lilly and Company, 1987-1990 "Modeling with Stella" A. Bingham, Lilly Modeling Conference, Oct 1987 "Graphic Display of Data" V. Maffei, A. Bingham, ACS Sectional Meeting, Technicians Symposium, ~1983 "Mathematical Modeling of Chemical Reactions" A. Bingham, University of Puerto Rico, Mayaguez, Dept. Seminar, ~1982 "Industrial Chemistry: Scaleup Concerns" A. Bingham, Purdue University, Dept of Chemistry, Guest Lecturer, Chem Course, ~1980 "Kinetic and Thermodynamic Forms of Triphenylphosphite Dichloride" A. Bingham, MC705/742 Lecture Series, Eli Lilly and Company, ~1980. Training Courses: Managing R&D for Innovation, May 1997. Industrial Relations Center; Caltech University 1. Case studies on innovation 2. Corporate cultures for research 3. Organization architecture and technical teams
Maximising the Efficiency of Drug Development, Nov 1994. Management Centre of Europe; Centre for Medicines Research 1. Industry Benchmarking 2. Development Timelines and Organizational Structures 3. Quantitative Decision Analysis
Performance Management Process, Feb 1994. Lilly; DDI 1. Performance Management 2. Personnel Development
Global Senior Management Conference at Westfields, Dec 1992. Harvard, Duke, U. of Mich Fac. 1. Change, external forces 2. Case studies 3. Strategy Product Development Capabilities, July 1991. Harvard GSB. 1. Product Development Strategies 2. Time to market 3. Heavyweight Teams Statistical Thinking, May 1991. IUPUI; Univ of Tenn. 1. Control Charts 2. Design of Experiments 3. Statistical Analysis
Management of Strategy, Mar 1991. University of Tennessee 1. Suprasystems 2. Strategic organization 3. Customer focus Advanced Management Conference, June 1990. Babson College; Harvard Bus School; Eli Lilly 1. Financial ratios 2. Strategic case studies
Interpretation of GMPs, March 1990. Eli Lilly and Co.
Management Overview of GMPs, Nov 1989. Eli Lilly and Co
Simulation Modeling for Decision Making, June 1989. Institute for Professional Education 1. Generating distribution densities 2. Random number theory 3. Statistical evaluation of model output
Establishing and Implementing a Customer Driven Strategy, Feb 1989. Turning Point Associates 1. Industry trends 2. Mission and Vision Statements
Managing Performance Excellence Teams, Jan 1989. Eli Lilly and Company; Florida Power and Light 1. Performance Excellence Overview and Principles 2. Effective/Ineffective Behavior; Team Dynamics; Recognition
New Employee Safety Training, May 1988. Developed for Lilly Research Laboratories
Managing for Excellence, Feb 1988. Wilson Learning Corporation; Eli Lilly and Company 1. Manager as Developer 2. Overarching Goals 3. Shared Responsibility Teams
Personal Influence and Leadership (Course Evaluation), 1988. Eli Lilly and Company
Effective Meetings, Nov 1987. Wilson Learning Corp; Eli Lilly and Company
New Managers Program, Apr/Jul 1987. Development Dimensions Int; Eli Lilly and Company 1. Using Behavior Information 2. Situational Leadership II (Blanchard Training and Dev)
Targeted Selection, Mar 1987. Development Dimensions Int; Eli Lilly and Company 1. Focusing on Past Behavior 2. Interviewing Skills
Management Development, Jan 1987. Columbia University; Pharmaceutical Manuf. Assn. 1. Management Authority 2. Organizational Analysis and Problem Solving; Decision Making 3. Motivation, Leadership and Communication
Skills Awareness Workshop Observer Training, Jan 1987. Eli Lilly and Company 1. Leadership, Communication, Interpersonal Skills
Performance Appraisal and Coaching, Nov 1986. Eli Lilly and Company 1. Observing and Classifying Behavior 2. Feedback 3. Development Plan
Time Management, Oct 1986. Charles R. Hobbs Corp; Eli Lilly and Company
Results Through People, Sep 1986. Wilson Learning; Eli Lilly and Company 1. Management Styles 2. Conflict Resolution
Statistics for Experimenters, 1985. Purdue University; Eli Lilly and Co.
Managing Interpersonal Effectiveness, May 1984. Eli Lilly and Company 1. Interpersonal Skills
Management Orientation: Jun 1983. Eli Lilly and Company
Leadership and Group Dynamics: Mar 1982. Eli Lilly and Company
Chemical Engineering for Chemists, 1982. Eli Lilly and Co; American Chemical Society
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